Withdrawn 36th Lorne Cancer Conference 2024

A metabolic atlas of aging (NOT ATTENDING) (#148)

Steven E Pilley 1 , Dominik Awad 2 , Edgar Esparza 1 , Li Zhang 2 , Xuanyi Shi 1 , Darius Moaddeli 1 , Racheal Mulondo 1 , Sriraksha Kashyap 1 , Costas A Lyssiotis 2 , Peter James Mullen 1
  1. University of Southern California, Los Angeles, CALIFORNIA, United States
  2. University of Michigan, Ann Arbor, Michigan, United States

Metabolites are used to make DNA, RNA, proteins, energy, hormones, and other molecules that are essential for health. Altered metabolism occurs in many cancers and diseases that affect the eldery, but a key question remains: how does metabolism change throughout life? Answering this will uncover new knowledge about the aging process itself and unveil new precision strategies to target cancers in older adults and increase healthspan. Here, we use targeted and untargeted LC-MS-based metabolomics to describe how metabolism changes in 12 organs in male and female mice at 5 different ages from 4 weeks old until 24 months old. We also place this in the context of the Tabula Muris Senis, to give a rationale for organ-specific metabolic changes that could impact cancer development in older adults. This metabolic atlas of aging provides an invaluable resource that will impact multiple areas of research, including studies into oncogenesis and anti-tumor therapies.